Noncoding RNA Modulation for Cardiovascular Therapeutics
نویسندگان
چکیده
منابع مشابه
RNA Therapeutics for Treatment of Cardiovascular Diseases
Recent studies suggest that the majority of the human genome is transcribed, but only ≈2% account for protein coding exons. The remaining noncoding sequences include small noncoding RNAs, particularly microRNAs, which are ≈22 nucleotides in length. MicroRNAs posttranscriptionally control gene expression by targeting multiple mRNAs. By binding to the 3′UTR (untranslated region) of mRNAs, microRN...
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Noncoding RNAs (ncRNAs) are remarkably powerful, flexible, and pervasive cellular regulators. The involvement of these molecules in virtually all aspects of eukaryotic chromatin function is notable. Long and short ncRNAs play broadly complementary roles in these processes. Short ncRNAs underlie a programmable system of chromatin modification that silences mobile elements, identifies boundaries,...
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Despite substantial progress in understanding disease mechanisms and the approval of multiple new therapies, for the first time in 3 decades, we are witnessing an increase in overall cardiovascular deaths. Recently, the discovery of an attractive group of molecules known as long noncoding RNAs (lncRNAs) has introduced a new catalog of diagnostic and therapeutic opportunities for cardiovascular ...
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Eukaryotic gene expression is tightly regulated transcriptionally and post-transcriptionally by a host of noncoding (nc)RNAs. The best-studied class of short ncRNAs, microRNAs, mainly repress gene expression post-transcriptionally. Long noncoding (lnc)RNAs, which comprise RNAs differing widely in length and function, can regulate gene transcription as well as post-transcriptional mRNA fate. Col...
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Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner, yet little is known about their roles in lineage commitment. Here, we identified Braveheart (Bvht), a heart-associated lncRNA in mouse. Using multiple embryonic stem cell (ESC) differentiation strategies, we show that Bvht is required for progression of nascent mesoderm toward a cardiac fate. We find that Bvht i...
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ژورنال
عنوان ژورنال: Significances of Bioengineering & Biosciences
سال: 2018
ISSN: 2637-8078
DOI: 10.31031/sbb.2018.01.000513